Hospital for Diseases of the Nervous System

A case of hypertension is described. The patient's symptoms suddenly became acute. The heart remained compensated, but the progressive renal damage resulted in a fatal uraemia. Hyaline degenerative changes as in benign essential hypertension were found in the arterioles of the kidneys, suprarenals, pancreas, liver, and spleen. The vascular changes of the malignant phase were superimposed. In the kidney, suprarenal and pancreas necrotic arterioles showed fibrin and sometimes red blood-cells in their walls. Other evidence of the active progress of the hypertension and of renal involvement was furnished by proliferative changes in the glomeruli.